Shire Scientist, Antibody Engineering in Burlington, Massachusetts

We are seeking a talented and experienced scientist to join Protein and Antibody Engineering group at Shire. The candidate will contribute to advancement of research and early development pipeline of innovative biotherapeutics for unmet medical needs. This individual is expected to have a strong foundation in molecular biology techniques and a collaborative approach to scientific inquiry. The ideal candidate should display a high level of attention to detail, demonstrate leadership potential and possess intellectual curiosity for learning new techniques and approaches to drug discovery. Primary responsibilities include generating antibody leads using phage display, protein engineering and high throughput screening.

Essential functions:

  • Develop and implement phage display and other antibody discovery strategies to advance novel biotherapeutic products through discovery and optimization stages.

  • Responsible for cloning of various antibody formats (scFvs, Fabs, full length and bi-specific IgGs) into microbial and mammalian expression vector systems.

  • Eukaryotic and mammalian protein expression and purification.

  • Strong background in molecular cloning techniques including DNA and RNA extraction, PCR, RT-PCR, restriction enzyme digestions and site directed mutagenesis.

  • Characterization of potential leads by ELISA and flow cytometry screening using manual and automated methods.

  • Ability to accurately and clearly document, summarize and present experimental results.

  • Utilize journal articles and other scientific resources to design and implement experimental methods.

Responsibilities (% of time):

70% Experimental design and execution

10% Analyze, interpret, document and present experimental data

10% Participate in cross-functional project teams

10% Manage external vendors and interact with collaborators

Education & Experience Requirements:

MS with 5+ years of experience or PhD with 2-3 years of industry experience in Molecular Biology, Cell Biology, Biochemistry, Protein Chemistry or relevant field. Strong background in therapeutic antibody discovery and engineering.

Key Skills & Competencies:

  • Eukaryotic/mammalian expression construct design

  • Strong background in molecular biology

  • Experience with phage display techniques

  • Flow cytometry

  • Experience with automated instrumentation

  • Eukaryotic and mammalian protein expression and purification

  • ELISA and FACS (Flow Cytometry) screening using manual and automated methods

  • Experience with NCBI, IMGT, VectorNTI and Sequencher

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Reasonable Accommodations

Shire is committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please call 484-595-8400 and let us know the nature of your request and your contact information.

Shire is the leading global biotechnology company focused on serving people with rare diseases and other highly specialized conditions. We strive to develop best-in-class products, many of which are available in more than 100 countries, across core therapeutic areas including Hematology, Immunology, Neuroscience, Ophthalmics, Lysosomal Storage Disorders, Gastrointestinal/Internal Medicine/Endocrine and Hereditary Angioedema; and a growing franchise in Oncology.

Our employees come to work every day with a shared mission: to develop and deliver breakthrough therapies for the hundreds of millions of people in the world affected by rare diseases and other high-need conditions, and who lack effective therapies to live their lives to the fullest.