Shire Senior Scientist, GI/Metabolic in Cambridge, Massachusetts
We are seeking a talented and highly motivated biologist/pharmacologist to join the Gastrointestinal and Metabolic therapeutic area in the Discovery Research department. This individual will contribute to the advancement of a research and early development pipeline of innovative therapeutics for unmet medical needs. The ideal candidate will bring scientific rigor and intellectual curiosity to a role whose primary responsibilities are performing and managing in vitro and in vivo studies in support of ongoing programs.
Conduct pharmacology and mechanistic studies in a variety of in vitro and in vivo models of GI and Metabolic diseases
Manage external CROs to supplement in-house in vitro and in vivo efforts
Evaluate new target opportunities and construct target validation work plans
Collaborate closely with partners from Discovery Therapeutics and Nonclinical Development departments to drive project progressions
Prepare scientific presentations and actively participate in multidisciplinary team meetings
Generate scientific reports and, when appropriate, manuscripts for publication
Responsibilities (% of time):
Perform lab-based experiments
Analyze, interpret and summarize data; prepare data for presentation and reports
Manage external vendors and interact with collaborators
Present data at departmental and cross-functional team meetings as appropriate
MS/PhD in biology related field with 8+ years of industrial pharmaceutical experience in a Discovery setting or PhD with post-doctoral/industrial experience (3-5 years). Level and Title may be adjusted commensurate with experience.
Key Skills & Abilities:
Experience in developing and executing assays for primary in vitro pharmacology, including but not limited to binding formats, enzyme assays, reporter genes, cellular immunofluorescence, and ELISA
Experience in the use of genetically engineered models in cellular contexts and/or animal models of human disease
Familiarity with design of preclinical in vivo pharmacology studies, including pharmacokinetics-based dose selection, appropriate tissue analyses, and choice of relevant disease biomarkers
Review of relevant technical literature to enable project accelerations in highly competitive therapeutic spaces
Proficiency in communication of study plans and oral presentations.
Strong written and verbal communications skills
Computer skills including extensive experience with Microsoft Word, Excel, Power Point, and GraphPad PRISM or other statistical analysis/data visualization tools.
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Shire is the leading global biotechnology company focused on serving people with rare diseases and other highly specialized conditions. We strive to develop best-in-class products, many of which are available in more than 100 countries, across core therapeutic areas including Hematology, Immunology, Neuroscience, Ophthalmics, Lysosomal Storage Disorders, Gastrointestinal/Internal Medicine/Endocrine and Hereditary Angioedema; and a growing franchise in Oncology.
Our employees come to work every day with a shared mission: to develop and deliver breakthrough therapies for the hundreds of millions of people in the world affected by rare diseases and other high-need conditions, and who lack effective therapies to live their lives to the fullest.