Shire Senior Scientist, GI/Metabolic in Cambridge, Massachusetts
We are seeking a talented and highly motivated biologist to join the Inborn Errors of Metabolism (IEM) therapeutic area in the Rare Genetic Disease Research department. This individual will contribute to the advancement of a discovery research and early development pipeline of innovative therapeutics for unmet medical needs. The scientific focus for this role is to identify and validate specific metabolic pathways which can be leveraged to treat a select group of disorders within amino acid, ammonia/urea, and/or fatty acid metabolism. The ideal candidate will bring scientific rigor and intellectual curiosity to a role whose primary responsibilities are performing and managing in vitro, ex vivo, and in vivo studies in support of ongoing programs. In addition to leading the discovery efforts on novel IEM targets, the candidate can expect to have a biology lead role on new drug discovery programs.
Conduct pharmacology and mechanistic studies in a variety of in vitro and in vivo models of metabolic diseases
Manage external CROs to supplement in-house in vitro and in vivo efforts
Evaluate the literature and design experiments to drive target validation and drug discovery programs
Collaborate closely with partners from Discovery Therapeutics and Nonclinical Development departments to drive project progressions
Leadership skills to manage 1-3 direct reports and work in a matrixed group
Prepare scientific presentations and actively participate in multidisciplinary team meetings
Generate scientific reports and, when appropriate, manuscripts for publication
Job Function and Description
Perform lab-based experiments
Manage external vendors and interact with collaborators
Analyze, interpret and summarize data; prepare data for presentation and reports
Present data at departmental and cross-functional team meetings as appropriate
Education and Experience Requirements
MS/PhD in biochemistry, bio/chemical engineering, or cell biology field with 8+ years of industrial pharmaceutical experience in a Discovery setting or PhD with post-doctoral/industrial experience (3-5 years). Level and Title may be adjusted commensurate with experience.
Key Skills, Abilities, and Competencies
Proficient in the analytical methods used for multiplexed biomarker analysis in metabolomics, proteomics, and transcriptomics
Experience in the use of genetically engineered models in cellular contexts and/or animal models of human disease
Experience with modulating/measuring pathways in cell metabolism and incorporating relevant disease biomarkers
Proficiency in communication of study plans and oral presentations.
Strong written and verbal communications skills
Computer skills including extensive experience with Microsoft Word, Excel, Power Point, and GraphPad PRISM, Vortex/SpotFire or other statistical analysis/data visualization tools.
Internal and External Contacts
Vendors: specialized equipment used for experimentation; materials and reagents used for experimentation.
External collaborators/CRO’s: guidance on method development, knowledge, and assay transfer
Internal: entire research staff; members of cross-functional teams, business development, new products and clinical
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Shire is the leading global biotechnology company focused on serving people with rare diseases and other highly specialized conditions. We strive to develop best-in-class products, many of which are available in more than 100 countries, across core therapeutic areas including Hematology, Immunology, Neuroscience, Ophthalmics, Lysosomal Storage Disorders, Gastrointestinal/Internal Medicine/Endocrine and Hereditary Angioedema; and a growing franchise in Oncology.
Our employees come to work every day with a shared mission: to develop and deliver breakthrough therapies for the hundreds of millions of people in the world affected by rare diseases and other high-need conditions, and who lack effective therapies to live their lives to the fullest.