Shire Purification Engineer in Lessines, Belgium


The Purification Engineer is responsible for design, construction/modification, commissioning and qualification of Purification/Clean Utilities systems according to EHS, GMP and Best Engineering Practices requirements.

Implicated in day to day manufacturing operations for problem solving/improvement deployement as a Subject Matter Expert regarding purification and clean utilities systems.

He trains and supports junior purification Engineers and external contractants.

Main responsibilities

  1. Projects In scope of CAPEX programs and continous improvement of new/existing systems, the incumbent must be able to manage medium projects without assistance. In particular, the position implies :
  • Basic Design and support for budgets preparation

  • Detailed Design of new or modified systems

  • Tenders writing, orders handling, following of construction, and start-up of equipments

  • Writing and execution of validation packages (URS/FSDS/Commissioning/engineerin part of IQOQ)

  • Training of employees impacted by changes and new equipments

  • Ensure compliance to EHS, cGMP, regulatory and Best Engineering Practices requirements

  • Lead multidisciplinary project teams

  1. Troubleshooting of equipment/systems: support day-to-day requests from purification manufacturing and maintenance, active participation in daily operational meetings with actions follow-up, handling troubleshooting change requests, supports to 24h/7d service as required.

Use problem-solving skills and Subject Matter Experts in order to develop robust solutions to complex issues.

  1. Continuous improvement : Be on the floor to study and recommend improvement of existing equipments to minimize production down time. Provide suggestions on how to improve an existing equipment if needed

  2. Subject Matter Expertise Development : Develop technical expertise on purification processes / Clean utilities systems to be a Subject Matter.

  3. Coaching : Training and support of newly hired Engineers. Coordination of engineering sub-contractors or engineering companies


  • Master Degree in Engineering

  • Seven plus (7+) years of experience in a process engineering function within a biotech/pharmaceutical operations/manufacturing environment

  • Knowledge of purification equipment & related clean utilities is required

  • Clean process/Clean utilities technical skills

  • Must have experience in project: design/construction/commissioning in a regulated environment.

  • Demonstrated experience in GEP, GMP and validation approach in pharmaceutical industrie

  • Working knowledge of current Good Manufacturing Practices (cGMP) and current Good Documentation Practices (cGDP)

  • Good communication, leadership and organizational skills

  • Must be a team player prepared to lead, work in, embrace a team based culture.

  • Client oriented, rigorous, synthetic and analytic thinking

  • Good written and verbal skills in French and English.

  • Must be proficient with standard office software (Word, Excel and PowerPoint)

Type de contrat: CDI

Horaire: journée

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Shire is the leading global biotechnology company focused on serving people with rare diseases and other highly specialized conditions. We strive to develop best-in-class products, many of which are available in more than 100 countries, across core therapeutic areas including Hematology, Immunology, Neuroscience, Ophthalmics, Lysosomal Storage Disorders, Gastrointestinal/Internal Medicine/Endocrine and Hereditary Angioedema; and a growing franchise in Oncology.

Our employees come to work every day with a shared mission: to develop and deliver breakthrough therapies for the hundreds of millions of people in the world affected by rare diseases and other high-need conditions, and who lack effective therapies to live their lives to the fullest.