Shire Post-Doctorate - DMPK in Lexington, Massachusetts


The Post-Doctoral scientist will be responsible for building quantitative systems pharmacology (QSP) and mechanistic pharmacokinetic (PK)/pharmacodynamic (PD) models in support of drug discovery and development programs. The individual will also support the development of nonclinical models and apply modeling and simulation tools to translate PK/PD outcomes from nonclinical species to human in support of research and development project teams.

Responsibilities (% of Time):


Developing and applying mechanistic PK, PKPD and QSP models for translational support of discovery and development programs.


Building experience with novel animal models that will improve the prediction of antibody PK from animal to humans


Evaluating and implementing modeling and simulation software and in-silico tools in DMPK


  • PhD in appropriate field in the engineering/pharmaceutical sciences and training in modeling of chemical and biological processes.

  • Demonstrated ability in modeling and simulation and proficient in the use of common M&S software.

Key Skills and Competencies:

  • Ability to provide QSP, physiologically-based PK (PBPK) and PK/PD model building expertise.

  • Ability to develop interdisciplinary collaborations with Research and Development colleagues

  • Effective communication skills and ability to articulate positions and convey information within RNCD and as needed on GDT program teams

  • The ideal candidate will be motivated, creative, energetic, resourceful and adaptable, responding constructively to challenging new ideas, information, situations or criticism.

  • The candidate should have strong mathematical capabilities and experience with modeling software.

  • Exceptional oral and written communication skills with a demonstrated ability to write scientific peer-reviewed publications

Equal Employment Opportunity

Shire is an Equal Opportunity Employer committed to a diverse workforce. Shire will not discriminate against any worker or job applicant on the basis of race, color, religion, gender, national origin, ancestry, age, sexual orientation, marital or civil partnership status, pregnancy, gender reassignment, non-job related mental or physical disability, genetic information, veteran status, military service, application for military service, or membership in any other category protected under law.

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Reasonable Accommodations

Shire is committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please call 484-595-8400 and let us know the nature of your request and your contact information.

Shire is the leading global biotechnology company focused on serving people with rare diseases and other highly specialized conditions. We strive to develop best-in-class products, many of which are available in more than 100 countries, across core therapeutic areas including Hematology, Immunology, Neuroscience, Ophthalmics, Lysosomal Storage Disorders, Gastrointestinal/Internal Medicine/Endocrine and Hereditary Angioedema; and a growing franchise in Oncology.

Our employees come to work every day with a shared mission: to develop and deliver breakthrough therapies for the hundreds of millions of people in the world affected by rare diseases and other high-need conditions, and who lack effective therapies to live their lives to the fullest.