Shire Scientist, Immunology in Lexington, Massachusetts


Highly motivated Immunologist will design and carry out experiments primarily related to cellular and molecular immunology. Knowledge of a diverse range of immunology approaches, including either innate or adaptive experimental systems is required. Scientist will be responsible for both in vitro and in vivo studies. Additional responsibilities may include establishing experimental approaches to address mechanism of action of drug candidates such as cellular uptake and kinetics, localization and recycling of drug product within target cells.

Employee may be expected to work with laboratory animals and perform in vivo experiments on models of human disease.

Employee will also interact with support personnel from other departments, as well as with external vendors. Preparation of scientific reports and participation in team-wide scientific presentations is required.

Responsibilities, % of time:

  • Become proficient at operating and maintaining analytical tools of interest (10%).

  • Develop and perform assays for measuring cellular activity and endpoints of interest, including flow cytometry, tissue culture of immune cells, immune cell isolation from human and rodent samples (70%).

  • Analyze, interpret and summarize data; prepare data for presentation and reports (5%).

  • Present data at departmental and cross-functional team meetings as appropriate (10%).

  • Perform routine literature searches to stay current in immunology and related fields (5%).


BS/MS in biology related field with 5+ plus years of industrial experience in performing analytical methods for detecting and measuring cellular activity of drug candidates or PhD in biological field, preferably with immunological experience.

Key Skills & Competencies:

  • Mammalian cell culture and transfection techniques, including immune cells.

  • Hands on experience and proficiency with the use of analytical tools and biochemical techniques for measuring biomarkers (e.g. Confocal microscopy, Flow Cytometry, ELISA, Western blot, spectrophotometry, fluorimetry, molecular biology, transfections, retroviral based gene transfer and expression, PCR and RT-PCR, protein labeling and modification)

  • Ability to implement new technologies within the lab, especially cellular based imaging platforms such as confocal microscopy and flow cytometry

  • Demonstrated capability for high quality work and keen attention to detail

  • Strong flexibility and adaptability skills

  • Strong interpersonal skills

  • Ability to function independently

  • Proficiency in technical writing and presentation

  • Strong computer skills including extensive experience with Microsoft Word, Excel, and Power Point.

Equal Employment Opportunity

Shire is an Equal Opportunity Employer committed to a diverse workforce. Shire will not discriminate against any worker or job applicant on the basis of race, color, religion, gender, national origin, ancestry, age, sexual orientation, marital or civil partnership status, pregnancy, gender reassignment, non-job related mental or physical disability, genetic information, veteran status, military service, application for military service, or membership in any other category protected under law.

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Reasonable Accommodations

Shire is committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please call 484-595-8400 and let us know the nature of your request and your contact information.

Shire is the leading global biotechnology company focused on serving people with rare diseases and other highly specialized conditions. We strive to develop best-in-class products, many of which are available in more than 100 countries, across core therapeutic areas including Hematology, Immunology, Neuroscience, Ophthalmics, Lysosomal Storage Disorders, Gastrointestinal/Internal Medicine/Endocrine and Hereditary Angioedema; and a growing franchise in Oncology.

Our employees come to work every day with a shared mission: to develop and deliver breakthrough therapies for the hundreds of millions of people in the world affected by rare diseases and other high-need conditions, and who lack effective therapies to live their lives to the fullest.