Shire Jobs

The Prives Lab in Department of Biological Sciences is seeking an Associate Research Scientist. The incumbent should have a full set of experimental skills with human cancer cell lines, including cell culture protocols, protein analyses, RT PCR and cell death assays. In addition, the applicant will be trained in computational biology using patient derived datasets with a focus on p53 signaling, long non-coding RNAs and generation of classifiers for cancer diagnostic purposes.

The responsibilities of this position will include:

• Analysis of complex, multi-omics datasets such as The Cancer Genome Atlas (TCGA), which is one of the largest repositories of data from cancer patients.
• Identification of potential biomarkers associated with patient survival and response to therapy.
• Comprehensive characterization of genes that are mutated or otherwise altered in cancers in a mutually exclusive manner with TP53, which is the most frequently mutated gene across cancers.
• Mentoring students and colleagues on projects that require sophisticated statistical analysis.
• Working closely with collaborators, including on multi-institutional program project grants, for statistical validation of datasets.
• Experimental verification of in silico results utilizing in vitro and in vivo methods involving cell culture, cell viability assays, gene expression analysis through Quantitative Polymerase Chain Reaction (Q-PCR), protein expression analysis using immunoblotting, cell cycle assays with flow cytometry among others.
• Preparing reports for grant submissions and drafting manuscripts detailing the results of studies for publication.

PhD in biological sciences.

All applications must be submitted through Columbia's online Academic Search and Recruiting portal (ASR). To apply, please upload a cover letter and CV.